927570
MST-alkyne
≥95%
Synonym(s):
5-(Methylsulfonyl)-1-(4-(prop-2-yn-1-yloxy)phenyl)-1H-tetrazole
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About This Item
Empirical Formula (Hill Notation):
C11H10N4O3S
CAS Number:
Molecular Weight:
278.29
MDL number:
NACRES:
NA.22
UNSPSC Code:
12352101
Application
MST-alkyne is a probe that can be used to label cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications . The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis . Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow .
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Profiling the proteome-wide selectivity of diverse electrophiles
Zanon, et al
ChemRxiv : the preprint server for chemistry (2021)
Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 927570-50MG | 04065268057612 |