927732
C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride
≥95%
Synonym(s):
2-(2,2-Difluoro-3-(4-(piperazin-1-yl)butoxy)propoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide Hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H35F2N5O6 · xHCl
Molecular Weight:
551.58 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
powder
ligand
C5 Lenalidomide
Quality Level
assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=CC=C31.Cl
InChI
1S/C26H35F2N5O6.ClH/c27-26(28,16-38-12-2-1-9-32-10-7-29-8-11-32)17-39-15-23(35)30-19-3-4-20-18(13-19)14-33(25(20)37)21-5-6-22(34)31-24(21)36;/h3-4,13,21,29H,1-2,5-12,14-17H2,(H,30,35)(H,31,34,36);1H
InChI key
NWCOGWMYGNQKPZ-UHFFFAOYSA-N
Application
Protein degrader building block C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a fluorinated linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Targeted Protein Degradation
Targeted Protein Degradation
signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2
target_organs
Blood
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 927732-50MG | 04065268348215 |