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Merck
CN

927813

PFPSA-alkyne

≥95%

Synonym(s):

N-(But-3-yn-1-yl)-2,3,4,5,6-pentafluorobenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C10H6F5NO2S
Molecular Weight:
299.22
NACRES:
NA.22
UNSPSC Code:
12352101
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Quality Level

assay

≥95%

form

powder

storage temp.

−20°C

Application

PFPSA-alkyne is a probe that can be used to label cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitave applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016).



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Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Profiling the proteome-wide selectivity of diverse electrophiles.
Zanon P R A, et al.
ChemRxiv : the preprint server for chemistry (2021)



Global Trade Item Number

SKUGTIN
927813-50MG04065268233443