930687
2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride
≥95%
Synonym(s):
3-((3-Aminophenyl)amino)piperidine-2,6-dione hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C11H13N3O2 · xHCl
CAS Number:
Molecular Weight:
219.24 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28
Assay:
≥95%
Quality Level
assay
≥95%
reaction suitability
reagent type: ligand
functional group
amine
storage temp.
2-8°C
SMILES string
O=C1NC(C(CC1)NC2=CC(N)=CC=C2)=O.[xHCl]
Application
2,6-Piperidinedione, 3-[(3-aminophenyl)amino] hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| C102814-10ML | 04061833460511 |
| 92509-100ML | 04061836693411 |
| C102814-100ML | 04061833460504 |
| C102814-25ML | 04061833460528 |
| 92509-500ML | 04061836693428 |
| 930687-50MG | 04065268923030 |