934178
TissueFab® bioink
(GelHAHep)MA Vis/405 nm, low endotoxin
Synonym(s):
3D Bioprinting, Bioink, Controlled Release, GelMA, Gelatin, Gelatin Methacryloyl, HAMA, Heparin, Heparin Methacrylate, Hyaluronan, Hyaluronic Acid, Hyaluronic Acid Methacrylate, Hydrogel
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
NACRES:
NA.28
UNSPSC Code:
12352201
Quality Level
sterility
0.2 μm filtered
form
gel form
contains
<50 EU/mL Endotoxin
composition
Gelatin, Hyaluronic acid, Heparin, Alginate
impurities
<5 CFU/g Bioburden ( fungal) , <5 CFU/g Bioburden (Total Aerobic)
color
pale yellow to colorless
pH
6.5-7.5
compatibility
3D bioprinting, extrusion bioprinting
storage temp.
2-8°C
General description
TissueFab® bioink -(GelHAHep)MA Vis/405 nm, low endotoxin formulation can be used to bioprint cell-laden hydrogels in the desired shape without any supporting material. This bioink can be crosslinked in one step using exposure to 405 nm light for further culture and maturation of cells for tissue engineering and regenerative medicine applications.
Application
Currently, there is a need for high-quality, commercially available ready-to-use bioink formulations to enable the reproducible fabrication of synthetic tissues and organs by 3D Bioprinting
- drug discovery
- in-vitro disease models
- regenerative medicine-cell-cultured meat
Features and Benefits
- Bioprinting models replicate biology for drug discovery and in vivo applications
- Sterile, low endotoxin-Batch control offers reproducible models for preclinical toxicology testing and drug screening
- Extended shelf-life & stability
Other Notes
Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications.
The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water. Heparin-based bioinks are used in tissue engineering, 3D bio-printing, and drug delivery applications.
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid/N-acetyl-D-glucosamine found primarily in connective tissues. HA-based hydrogels are prevalent in tissue engineering, 3D bioprinting, and drug delivery applications. The methacrylate (MA) functionalized hyaluronic acid is photo-cross-linkable.
Low Endotoxin, low bioburden: Endotoxins can negatively impact cellular growth, morphology, differentiation, inflammation, and protein expression. The bioburden is the number of contaminated organisms found in a given amount of material.
We test each lot for endotoxins in addition to total bioburden (aerobic and fungal) to minimize unwanted interactions. For more information: Cell Culture FAQs: Bacterial Endotoxin Contamination
The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water. Heparin-based bioinks are used in tissue engineering, 3D bio-printing, and drug delivery applications.
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.
Hyaluronic acid (HA) is a linear polysaccharide of alternating D-glucuronic acid/N-acetyl-D-glucosamine found primarily in connective tissues. HA-based hydrogels are prevalent in tissue engineering, 3D bioprinting, and drug delivery applications. The methacrylate (MA) functionalized hyaluronic acid is photo-cross-linkable.
Low Endotoxin, low bioburden: Endotoxins can negatively impact cellular growth, morphology, differentiation, inflammation, and protein expression. The bioburden is the number of contaminated organisms found in a given amount of material.
We test each lot for endotoxins in addition to total bioburden (aerobic and fungal) to minimize unwanted interactions. For more information: Cell Culture FAQs: Bacterial Endotoxin Contamination
Legal Information
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
Still not finding the right product?
Explore all of our products under TissueFab® bioink
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 934178-10ML-PW | 04065270067241 |
| 934178-10ML | 04065270067234 |