n-Butyllithium solution

n-Butyllithium (n-BuLi) is an organolithium reagent commonly used as a strong base in organic synthesis. It is also used as a lithium source for a wide range of lithium bases, such as lithium amides, acetylides, and alkoxides. This n-BuLi is a solution in poly-α-olefin (PAO)/hexanes solvent mixture is considered non-pyrophoric which is demonstrated using EPA’s SW-846 Test Method 1050.

n-BuLi can be used as a strong base to form corresponding lithium salts by the deprotonation of nitrogen, oxygen, phosphorus, and carbon acids. Heterocyclic compounds, such as furans, thiophenes, oxazoles, pyrroles, etc, can be lithiated α to the ring heteroatom using n-BuLi. These lithiated salts react in situ with alkyl halides to obtain useful organic compounds by the formation of the C-C bond. n-BuLi is also a useful reagent for lithium–halogen exchange reactions. Synthesis of various other useful reagents such as lithium diisopropylamide (LDA) and diphenylphosphine is done by in situ reaction with n-BuLi In the polymerization of dienes, n-BuLi is employed as an initiator.




The product is also used in the following reactions:

• Anionic rearrangement reactions
  
• Metal-halogen interchange and transmetalation reactions
• Elimination reactions
• [1,2]- and [1,4]-Wittig rearrangement reaction
• Anionic homo-Fries rearrangement reaction
• Asymmetric carbolithiation

This n-BuLi formulation in PAO/hexanes is:

• Considered non-pyrophoric demonstrated using EPA’s SW-846 Test Method 1050
• Maintains the same reactivity as traditional n-BuLi reagents
• Compatible with traditional lithiation additives like KOtBu or TMEDA
• More bench stable than traditional n-BuLi reagents