Skip to Content
Merck
CN

Key Documents

View All Documentation

943517

(R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

≥95%

Synonym(s):

(1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- ; (1R)-1-(3-Aminophenyl)-3-(3,4-dimethoxyphenyl)propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate;, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 2-Piperidinecarboxylic acid, AP 3351

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C30H40N2O6
CAS Number:
195513-96-3
Molecular Weight:
524.65
Assay:
≥95%
Form:
solid
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥95%

form

solid

functional group

amine

storage temp.

2-8°C

SMILES string

O=C(OC(C=1C=CC=C(N)C1)CCC2=CC=C(OC)C(OC)=C2)C3N(C(=O)C(=O)C(C)(C)CC)CCCC3

InChI

1S/C30H40N2O6/c1-6-30(2,3)27(33)28(34)32-17-8-7-12-23(32)29(35)38-24(21-10-9-11-22(31)19-21)15-13-20-14-16-25(36-4)26(18-20)37-5/h9-11,14,16,18-19,23-24H,6-8,12-13,15,17,31H2,1-5H3/t23-,24+/m0/s1

InChI key

IIDSDBBDZNDWCN-BJKOFHAPSA-N

General description

SLF (Synthetic Ligand of FKBP) is a small-molecule ligand designed to bind FKBP12 and related FK506-binding proteins. It mimics immunosuppressant binding (like FK506/rapamycin) but is non-immunosuppressive, making it useful as a chemical biology tool in studies of protein interactions and targeted protein degradation (e.g., PROTAC designs).

Application

  • Chemical biology & target validation: Studies of FKBP function and protein complex formation.
  • PROTAC synthesis: Serves as an FKBP-binding “warhead” or recruiting moiety in degrader constructs.
  • Protein–protein interaction modulation: Used to stabilize or disrupt FKBP-mediated interactions.

Features and Benefits

  • Selective FKBP binder: Engages FKBP proteins, enabling modulation or recruitment in biological systems.
  • Useful in PROTAC/chemical dimerizer designs: Acts as a recruitment handle to bring FKBP-tagged target proteins into proximity with ligases or partners.
  • Versatile research reagent: Applicable in cell-based assays, protein interaction studies, and probe development.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
943517-5MG04065274057392