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A48105

Cycloleucine

Name: Cycloleucine
Brand: ALDRICH

97%

Synonym(s):

1-Aminocyclopentanecarboxylic acid

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About This Item

Linear Formula:

H₂NC₅H₈CO₂H

CAS Number:

52-52-8

Molecular Weight:

129.16

UNSPSC Code:

12352209

NACRES:

NA.22

PubChem Substance ID:

24890914

EC Number:

200-144-6

Beilstein/REAXYS Number:

636626

MDL number:

MFCD00001381

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Properties

Quality Level

100

assay

97%

form

crystals

reaction suitability

reaction type: solution phase peptide synthesis

technique(s)

ligand binding assay: suitable

mp

320 °C (dec.) (lit.)

application(s)

peptide synthesis

SMILES string

NC1(CCCC1)C(O)=O

InChI

1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)

InChI key

NILQLFBWTXNUOE-UHFFFAOYSA-N

Description

General description

Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.

Application

Cycloleucine can be used as a building block to synthesize:

Phosphonylmethylaminocyclopentane-1-carboxylic acid by reacting with paraformaldehyde and diethylphosphite via Kabachnik-Field′s reaction.
Benzo[b]thiophene-2-carboxylic acid {1-[1-(R)-(3-morpholin-4-ylpropylcarbamoyl)-2-phenylethylcarbamoyl]cyclopentyl}-amide, (MEN14268) as potential tachykinin NK2 receptor antagonist.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro.

K J Helbig et al.

Scientific reports, 9(1), 15598-15598 (2019-11-02)

The role of interferon and interferon stimulated genes (ISG) in limiting bacterial infection is controversial, and the role of individual ISGs in the control of the bacterial life-cycle is limited. Viperin, is a broad acting anti-viral ISGs, which restricts multiple

across Cell Membranes

Biochemical Ecotoxicology. Principles and Methods, 1, 157-157 (2012)

Peptide synthesis in room temperature ionic liquids

Vallette H, et al.

Tetrahedron Letters, 45(8), 1617-1619 (2004)

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Global Trade Item Number

SKU	GTIN
A48105-10G	04061833484043
A48105-5G	04061833467060