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A79809

5-Aminosalicylic acid

Name: 5-Aminosalicylic acid
Brand: ALDRICH

95%

Synonym(s):

5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Linear Formula:

H₂NC₆H₃-2-(OH)CO₂H

CAS Number:

89-57-6

Molecular Weight:

153.14

UNSPSC Code:

12352106

NACRES:

NA.22

PubChem Substance ID:

24891301

EC Number:

201-919-1

Beilstein/REAXYS Number:

2090421

MDL number:

MFCD00007877

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Properties

Quality Level

200

assay

95%

form

powder with small lumps

reaction suitability

reaction type: solution phase peptide synthesis

mp

275-280 °C (dec.) (lit.)

application(s)

detection
peptide synthesis

SMILES string

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

InChI key

KBOPZPXVLCULAV-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240), PPARG(5468), PTGS1(5742), PTGS2(5743)

Description

Application

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H317,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Inflammation and disease duration have a cumulative effect on the risk of dysplasia and carcinoma in IBD: a case-control observational study based on registry data.

Urpo Nieminen et al.

International journal of cancer, 134(1), 189-196 (2013-06-26)

Patients with long-standing inflammatory bowel disease (IBD) have an increased risk for colorectal carcinoma (CRC). Earlier studies suggest that the severity of inflammation is an independent risk factor for CRC in ulcerative colitis (UC). We investigated the role of histological

Randomised clinical trial: mesalazine (Salofalk granules) for uncomplicated diverticular disease of the colon--a placebo-controlled study.

W Kruis et al.

Alimentary pharmacology & therapeutics, 37(7), 680-690 (2013-02-19)

Robust evidence regarding medical intervention for symptomatic uncomplicated colonic diverticular disease (DD) is sparse. To investigate mesalazine (Salofalk granules) in this setting. In a double-blind, placebo-controlled, multicentre, 6-week trial, patients were randomised to mesalazine 1000 mg three times daily or placebo.

Colorectal cancer prevention in inflammatory bowel disease and the role of 5-aminosalicylic acid: a clinical review and update.

David T Rubin et al.

Inflammatory bowel diseases, 14(2), 265-274 (2007-10-13)

A roundtable consensus meeting was held to consolidate current knowledge on the etiology of colorectal cancer in patients with inflammatory bowel disease and to review current strategies, both diagnostic and preventive, specifically addressing the role of 5-aminosalicylic acid. Specific topics

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Global Trade Item Number

SKU	GTIN
A79809-5G	04061833390887
A79809-100G	04061833390870