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B62404

1-Bromo-3-chloropropane

Name: 1-Bromo-3-chloropropane
Brand: ALDRICH

99%

Synonym(s):

I-BCP, Trimethylene bromochloride, Trimethylene chlorobromide

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About This Item

Linear Formula:

Cl(CH₂)₃Br

CAS Number:

109-70-6

Molecular Weight:

157.44

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891900

EC Number:

203-697-1

Beilstein/REAXYS Number:

605278

MDL number:

MFCD00000998

Assay:

99%

Form:

liquid

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Properties

Quality Level

200

assay

99%

form

liquid

refractive index

n20/D 1.486 (lit.)

bp

144-145 °C (lit.)

density

1.592 g/mL at 25 °C (lit.)

SMILES string

ClCCCBr

InChI

1S/C3H6BrCl/c4-2-1-3-5/h1-3H2

InChI key

MFESCIUQSIBMSM-UHFFFAOYSA-N

Description

Application

1-Bromo-3-chloropropane is generally used as C₃ linker/spacer in a wide range of molecules including medicinally important compounds. Some of the examples are:

Synthesis of polymer nanoparticles (NPs) to deliver doxorubicin, camptothecin, and cisplatin.
Synthesis of antiprion active acridine derivatives for prion infection.
Total synthesis of aspidospermine, aspidospermidine, and quebrachamine and (±)-crispine A.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H302,H331,H335,H341,H412

pcodes

P202 - P261 - P273 - P301 + P312 - P304 + P340 + P311 - P308 + P313

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Muta. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (?)-crispine A.

Coldham, Iain et al.

Organic & Biomolecular Chemistry, 7(8), 1674-1679 (2009)

Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors.

Jung, Frederic H et al.

Journal of Medicinal Chemistry, 49(3), 955-970 (2006)

Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: total syntheses of aspidospermine, aspidospermidine, and quebrachamine.