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C66056

4-(4-Chlorophenyl)-4-hydroxypiperidine

Name: 4-(4-Chlorophenyl)-4-hydroxypiperidine
Brand: ALDRICH

99%

Synonym(s):

Haloperidol metabolite I, 4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₄ClNO

CAS Number:

39512-49-7

Molecular Weight:

211.69

NACRES:

NA.22

PubChem Substance ID:

24892880

UNSPSC Code:

12352100

EC Number:

254-479-8

MDL number:

MFCD00006001

Assay:

99%

Form:

powder

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Properties

Quality Level

100

assay

99%

form

powder

mp

137-140 °C (lit.)

SMILES string

OC1(CCNCC1)c2ccc(Cl)cc2

InChI

1S/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2

InChI key

LZAYOZUFUAMFLD-UHFFFAOYSA-N

Description

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pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H315,H317,H318,H412

pcodes

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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[Chemical toxicological analysis of haloperidol metabolite 4-(4-chlorophenyl)-4-hydroxypipiridine in urine by high-performance liquid chromatography].

A B Skorniakova et al.

Sudebno-meditsinskaia ekspertiza, 52(1), 45-48 (2009-04-18)

Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of its metabolites also possess

Sensitive determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.

Yasuhiko Higashi et al.

Biomedical chromatography : BMC, 20(9), 964-970 (2006-03-01)

4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). After basic

Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage.

Ilse Weuts et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 387-393 (2005-05-17)

The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investigated in

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Global Trade Item Number

SKU	GTIN
C66056-5G	04061838353238