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C77007

Cholesteryl chloroformate

Name: Cholesteryl chloroformate
Brand: ALDRICH

95%

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₄₅ClO₂

CAS Number:

7144-08-3

Molecular Weight:

449.11

UNSPSC Code:

12352103

NACRES:

NA.23

PubChem Substance ID:

24892982

EC Number:

230-447-9

Beilstein/REAXYS Number:

3223154

MDL number:

MFCD00003633

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Properties

Quality Level

100

assay

95%

form

liquid crystal

optical activity

[α]27/D −28°, c = 2 in chloroform

mp

115-117 °C (lit.)

transition temp

crystalline phase to cholesteric phase 117.8 °C, cholesteric phase to isotropic phase 125.3 °C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(Cl)=O

InChI

1S/C28H45ClO2/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-26(29)30)13-15-27(20,4)25(22)14-16-28(23,24)5/h9,18-19,21-25H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,27+,28-/m1/s1

InChI key

QNEPTKZEXBPDLF-JDTILAPWSA-N

Description

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group.

Natalya S Petrova et al.

Nucleic acids research, 40(5), 2330-2344 (2011-11-15)

The conjugation of siRNA to molecules, which can be internalized into the cell via natural transport mechanisms, can result in the enhancement of siRNA cellular uptake. Herein, the carrier-free cellular uptake of nuclease-resistant anti-MDR1 siRNA equipped with lipophilic residues (cholesterol

Cholesterol-conjugated PEGylated PAMAM as an efficient nanocarrier for plasmid encoding interleukin-12 immunogene delivery toward colon cancer cells.

Elham Pishavar et al.

Biotechnology progress, 36(3), e2952-e2952 (2019-12-18)

IL-12 is a pleiotropic cytokine, which shows an ideal applicant for tumor immunotherapy, because of its features of creating an interconnection between innate (NK cells) and adaptive (cytotoxic T lymphocyte) immunity. IL-12 gene therapy is a useful technique to deliver

Recombinant high-density lipoprotein nanoparticles containing gadolinium-labeled cholesterol for morphologic and functional magnetic resonance imaging of the liver.

Mengjie Rui et al.

International journal of nanomedicine, 7, 3751-3768 (2012-08-14)

Natural high-density lipoproteins (HDL) possess important physiological functions to the transport of cholesterol from the peripheral tissues to the liver for metabolic degradation and excretion in the bile. In this work, we took advantage of this pathway and prepared two

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Global Trade Item Number

SKU	GTIN
C77007-100G	04061833521014
C77007-25G	04061833604762