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KITALYSIS-RCM

KitAlysis High-Throughput Medium (5, 6, 7) Ring Closing Metathesis Reaction Screening Kit - Pack of 2

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About This Item

NACRES:
NA.22
UNSPSC Code:
12161600
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product line

KitAlysis

reaction suitability

core: palladium, reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling

storage temp.

2-8°C

Application

Screening kit for ring closing metathesis. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.

Step-by-Step Guide for Ring Closing Metathesis/Cross Metathesis Reaction Screening Kit

Downloadable experimental excel file

Each kit contains 2 customizable screening sets that include the following components:
  • 6x4 pre-weighed catalysts in glass microvials loaded with stir bars and topped with cap mat.
  • 2 (2 mL) ampules each of of ClPh, PhMe, i-PrOAc, Me-THF, and TFA.
  • 1 KitAlysis 24-well reaction block replacement film.
  • 4 empty substrate stock solution reaction vials with stir bars.
  • 1 internal standard.
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reaction in parallel.
  • 20 μmol reactions with 1 μmol catalyst (5 mol%), 0.2 M concentration, and optional TFA additive.
  • Customizable and downloadable excel template for quick calculations and easy incorporation into electronic laboratory notebooks.

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC


Kit Components Only

Product No.
Description

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.
Description
SDS & Pricing

  • Grubbs Catalyst® M204, Umicore 3 µmol
    SDS

  • Hoveyda-Grubbs Catalyst® M720, Umicore, 97% 3 µmol
    SDS

  • Grubbs Catalyst® M102, Umicore, 97% 3 µmol
    SDS

  • Grubbs Catalyst® M207, Umicore 3 µmol
    SDS

  • Hoveyda-Grubbs Catalyst® M721, Umicore 3 µmol
    SDS

  • Hoveyda-Grubbs Catalyst® M722, Umicore 3 µmol
    SDS

  • Isopropyl acetate, anhydrous, ZerO2®, ≥99.6% 8 mL
    SDS

See All (11)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk

WGK 3

Regulatory Information

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Protocols

Catalyst screening kits, KitAlysis™, and TLC-MS analysis enable high-throughput synthesis and analysis for efficient reactions.

Articles

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Related Content

化学反应的设计和优化是有机合成研究的重要手段,通过改变反应参数,例如催化剂、反应体系pH值、反应溶剂、温度或时间等来节约成本、提高反应的选择性、产物的收率和纯度等

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

The Olefin Application Metathesis Application Guide provides - The Key Features of Metathesis, General Reaction Procedures, Guidance for Choosing the Correct Metathesis Route, A Metathesis Quick Guide

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High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in



Global Trade Item Number

SKUGTIN
KITALYSIS-RCM-2PAK04061833690345
KITALYSIS-RCM-2PK04061833690352