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Merck
CN

M0505

Methylamine hydrochloride

≥98%

Synonym(s):

Methanaminium chloride, Methylamine monohydrochloride, Methylammonium chloride, Monomethylammonium chloride

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About This Item

Linear Formula:
CH3NH2 · HCl
CAS Number:
Molecular Weight:
67.52
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-795-0
Beilstein/REAXYS Number:
3588822
MDL number:
Assay:
≥98%
Form:
powder or crystals
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Quality Level

assay

≥98%

form

powder or crystals

bp

225-230 °C/15 mmHg (lit.)

mp

231-233 °C (lit.)

solubility

H2O: 1 g in 10 mL, clear, colorless

SMILES string

Cl[H].CN

InChI

1S/CH5N.ClH/c1-2;/h2H2,1H3;1H

InChI key

NQMRYBIKMRVZLB-UHFFFAOYSA-N

General description

Methylamine hydrochloride is used as a buildingblock for the synthesis of various organic compounds.

Application

Methylamine hydrochloride can be used as a reactant to synthesize:
  • Betahistine via aza-Michael reaction with 2-vinylpyridine in water.
  • Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction.
  • Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes.
  • N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

408.7 °F - closed cup

flash_point_c

209.3 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Nicolas Fleury-Brégeot et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(31), 9564-9570 (2012-07-07)
Ammoniomethyl trifluoroborates are very powerful reagents that can be used to access biologically relevant aryl- and heteroaryl-methylamine motifs via Suzuki-Miyaura cross-couplings. Until now, this method was limited to the production of tertiary and primary amines. The synthesis of a large
Marco Dionisio et al.
Journal of the American Chemical Society, 134(15), 6540-6543 (2012-04-06)
Single-walled carbon nanotubes (SWCNTs) have been functionalized with highly selective tetraphosphonate cavitand receptors. The binding of charged N-methylammonium species to the functionalized SWCNTs was analyzed by X-ray photoelectron spectroscopy and confirmed by (31)P MAS NMR spectroscopy. The cavitand-functionalized SWCNTs were
Elisabeth Schwaiger et al.
Transplantation, 97(12), 1279-1285 (2014-03-14)
Luminex-based anti-HLA IgG detection on single-antigen flow beads (SAFB) represents a valuable tool for characterization of allosensitization patterns. Assay interpretation, however, may be impeded by false-low test results caused by the prozone effect. Recent experimental data have related this artifact



Global Trade Item Number

SKUGTIN
M0505-100G04061833993200
M0505-500G04061833993217