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N5757

α-Naphthoflavone

Name: α-Naphthoflavone
Brand: ALDRICH

≥98%

Synonym(s):

alpha-Naphthoflavone, 7,8-Benzoflavone

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₂O₂

CAS Number:

604-59-1

Molecular Weight:

272.30

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

57654455

EC Number:

210-071-1

Beilstein/REAXYS Number:

210494

MDL number:

MFCD00004985

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Properties

Quality Level

200

assay

≥98%

technique(s)

titration: suitable

color

white to yellow

mp

153-157 °C (lit.)

storage temp.

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)c4ccccc4

InChI

1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H

InChI key

VFMMPHCGEFXGIP-UHFFFAOYSA-N

Gene Information

human ... ADORA3(140), CYP1A2(1544), PRKDC(5591)
rat ... Adora1(29290), Adora2a(25369)

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone.

Iain A Murray et al.

Molecular pharmacology, 79(3), 508-519 (2010-12-04)

We have characterized previously a class of aryl hydrocarbon receptor (AHR) ligand termed selective AHR modulators (SAhRMs). SAhRMs exhibit anti-inflammatory properties, including suppression of cytokine-mediated acute phase genes (e.g., Saa1), through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures.

Barbara M Zietek et al.

SLAS discovery : advancing life sciences R & D, 23(3), 283-293 (2017-12-22)

With early assessment of inhibitory properties of drug candidates and their circulating metabolites toward cytochrome P450 enzymes, drug attrition, especially later in the drug development process, can be decreased. Here we describe the development and validation of an at-line nanofractionation

Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.

Min Ji Kim et al.

Environmental health perspectives, 120(4), 508-514 (2012-01-21)

Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT). Our aim was to study the effects of POPs on human adipose cells and rodent

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Global Trade Item Number

SKU	GTIN
N5757-5G	04061834117186
N5757-1G	04061834117179

Key Documents

α-Naphthoflavone

≥98%

Select a Size

About This Item

Quality Level

assay

technique(s)

color

mp

storage temp.

SMILES string

InChI

InChI key

Gene Information

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Articles

Peer Reviewed Papers

Global Trade Item Number