N8141
4-Nitroquinoline N-oxide
≥98%
Synonym(s):
4-NQO, 4-Nitroquinoline 1-oxide
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About This Item
Empirical Formula (Hill Notation):
C9H6N2O3
CAS Number:
Molecular Weight:
190.16
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-281-1
Beilstein/REAXYS Number:
165756
MDL number:
Assay:
≥98%
assay
≥98%
color
yellow to brown
mp
154-156 °C (lit.)
solubility
acetone: soluble, clear to hazy
storage temp.
−20°C
SMILES string
[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
InChI
1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
InChI key
YHQDZJICGQWFHK-UHFFFAOYSA-N
General description
4-Nitroquinoline N-oxide is a quinoline derivative widely used in chemical research and development.
Application
4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.
Biochem/physiol Actions
Skin and lung tumor initiator under experimental conditions.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
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Articles
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
MTA1 promotes tumorigenesis and development of esophageal squamous cell carcinoma via activating the MEK/ERK/p90RSK signaling pathway.
Nan, et al.
Carcinogenesis, 41, 1263-1272 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N8141-1G | 04061835559572 |
| N8141-250MG | 04061835559589 |
| N8141-5G | 04061835559596 |