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P21005

4-Phenylbutyric acid

Name: 4-Phenylbutyric acid
Brand: ALDRICH

99%

Synonym(s):

γ-Phenylbutanoic acid, ψ-Phenylbutanoic acid, 4-Phenyl-n-butyric acid, 4-Phenylbutanoic acid, Benzenebutyric acid

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About This Item

Linear Formula:

C₆H₅(CH₂)₃COOH

CAS Number:

1821-12-1

Molecular Weight:

164.20

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24898272

EC Number:

217-341-8

Beilstein/REAXYS Number:

638180

MDL number:

MFCD00004403

Assay:

99%

Form:

crystals

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Properties

Quality Level

200

assay

99%

form

crystals

bp

165 °C/10 mmHg (lit.)

mp

49-51 °C (lit.)

SMILES string

OC(=O)CCCc1ccccc1

InChI

1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)

InChI key

OBKXEAXTFZPCHS-UHFFFAOYSA-N

Description

General description

4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders.

Application

4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
It can also be used as a reactant in the synthesis of:

1-Tetralone using Lewis acid catalyst.
4,N-diphenylbutyramide.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.

Kolb PS, et al.

The International Journal of Biochemistry & Cell Biology, 61, 45-52 (2015)

Clean, reusable and low cost heterogeneous catalyst for amide synthesis

Comerford JW, et al.

Chemical Communications (Cambridge, England), 18(21), 2562-2564 (2009)

Induction of apoptosis coupled to endoplasmic reticulum stress through regulation of CHOP and JNK in bone marrow mesenchymal stem cells from patients with systemic lupus erythematosus

Guo G, et al.

Journal of immunology research (2015)

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Global Trade Item Number

SKU	GTIN
P21005-100G	04061838355393
P21005-25G	04061834358206