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P22370

trans-2-Phenylcyclopropylamine hydrochloride

Name: <I>trans</I>-2-Phenylcyclopropylamine hydrochloride
Brand: ALDRICH

97%

Synonym(s):

Tranylcypromine

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About This Item

Linear Formula:

C₆H₅C₃H₄NH₂·HCl

CAS Number:

1986-47-6

Molecular Weight:

169.65

NACRES:

NA.22

PubChem Substance ID:

24898296

UNSPSC Code:

12352100

MDL number:

MFCD00063602

Assay:

97%

Form:

solid

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Properties

Quality Level

200

assay

97%

form

solid

optical activity

[α]/D −1 to +1.0°, c = 1 in H₂O

mp

162-169 °C (lit.)

storage temp.

2-8°C

SMILES string

Cl.N[C@@H]1C[C@H]1c2ccccc2

InChI

1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1

InChI key

ZPEFMSTTZXJOTM-OULXEKPRSA-N

Description

Biochem/physiol Actions

Non-selective MAO-A/B inhibitor.

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

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Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.

Kaisa A Salminen et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(12), 1891-1904 (2015-09-25)

The cytochrome P450 2C19 (CYP2C19) enzyme plays an important role in the metabolism of many commonly used drugs. Relatively little is known about CYP2C19 inhibitors, including compounds of natural origin, which could inhibit CYP2C19, potentially causing clinically relevant metabolism-based drug

Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.

Yuki Ogawa et al.

European journal of pediatrics, 174(4), 509-518 (2014-09-25)

This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

James M Hill et al.

Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)

Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency

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Global Trade Item Number

SKU	GTIN
P22370-1G	04061825773032
P22370-2.5G	04061832113586