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P27100

N-Phenylmaleimide

Name: <I>N</I>-Phenylmaleimide
Brand: ALDRICH

97%

Synonym(s):

1-Phenyl-pyrrole-2,5-dione, 1-[4-(Acetoxy)phenyl]maleimide

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₇NO₂

CAS Number:

941-69-5

Molecular Weight:

173.17

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24898352

EC Number:

213-382-0

Beilstein/REAXYS Number:

125098

MDL number:

MFCD00005502

Assay:

97%

Form:

solid

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Properties

Quality Level

200

assay

97%

form

solid

bp

162-163 °C/12 mmHg (lit.)

mp

85-87 °C (lit.)

SMILES string

O=C1C=CC(=O)N1c2ccccc2

InChI

1S/C10H7NO2/c12-9-6-7-10(13)11(9)8-4-2-1-3-5-8/h1-7H

InChI key

HIDBROSJWZYGSZ-UHFFFAOYSA-N

Description

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H400

pcodes

P264 - P273 - P301 + P310 - P391 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation.

Vânia F Noldin et al.

Pharmacological reports : PR, 63(3), 772-780 (2011-08-23)

Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM)

Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.

Nicolas Matuszak et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(3), 263-271 (2011-12-01)

The endocannabinoid system is implicated in numerous physiopathological processes while more and more pieces of evidence wave the link between this complex machinery and cancer related phenomenon. In these lines, we confirmed the effects of 2-arachidonoylglycerol (2-AG), the main endocannabinoid

Diels-alder reaction of 2(1H)-pyridones acting as dienes.

Masato Hoshino et al.

Chemical & pharmaceutical bulletin, 56(4), 480-484 (2008-04-02)

Diels-Alder reactions between N-phenylmaleimide, acting as the dienophile, and 2(1H)-pyridones having a methoxy or a chloro substituent, were carried out, under atmospheric and high pressure conditions, to give the corresponding isoquinuclidine derivatives. Stereoselectivity of the Diels-Alder reactions was studied using

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Global Trade Item Number

SKU	GTIN
P27100-100G	04061834365174
P27100-25G	04061834365181