P57204
Pyridazine
98%
Synonym(s):
1,2-Diazabenzene, 1,2-Diazine, o-Diazine
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About This Item
Empirical Formula (Hill Notation):
C4H4N2
CAS Number:
Molecular Weight:
80.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-025-5
Beilstein/REAXYS Number:
103906
MDL number:
Assay:
98%
Quality Level
assay
98%
refractive index
n20/D 1.524 (lit.)
bp
208 °C (lit.)
mp
−8 °C (lit.)
density
1.103 g/mL at 25 °C (lit.)
SMILES string
c1ccnnc1
InChI
1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H
InChI key
PBMFSQRYOILNGV-UHFFFAOYSA-N
General description
Pyridazine is a mono-basic 1,2-diazine compound, which is commonly prepared by the reaction of 1,4-dicarbonyls with hydrazines. Pyridazine ring is found in many herbicides like credazine, pyridatol and many pharmaceutical drugs like cefozopran, olaparib, talazoparib, and cadralazine.
Application
Pyridazine can be used:
- As a building block to synthesize N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine derivatives as GSK-3 inhibitors.
- As a starting material in the synthesis of pharmacologically important pyrrolo[1,2-b]pyridazine derivatives.
- To prepare 1-(6-ethoxy-6-oxohexyl)pyridazin-1-ium bromide and 1-(2-bromoacetyl) pyridazinium bromide ionic liquids as corrosion inhibitors of steel under acidic conditions.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Masaomi Terajima et al.
European journal of pharmacology, 698(1-3), 455-462 (2012-11-28)
Given the key role p38 mitogen-activated protein kinase (MAPK) plays in inflammatory responses through the production of cytokines and inflammatory mediators, its inhibition is considered a promising therapeutic strategy for chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, inflammatory bowel
Jeffrey R Reimers et al.
Physical chemistry chemical physics : PCCP, 14(25), 8791-8802 (2012-04-26)
A unified picture is presented of water interacting with pyridine, pyridazine, pyrimidine, and pyrazine on the S(1) manifold in both gas-phase dimers and in aqueous solution. As (n,π*) excitation to the S(1) state removes electrons from the ground-state hydrogen bond
Emily A Peterson et al.
Bioorganic & medicinal chemistry letters, 22(15), 4967-4974 (2012-07-07)
mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P57204-50G | 04061833452677 |
| P57204-5G | 04061834392279 |