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About This Item
Empirical Formula (Hill Notation):
C45H70D6O2
CAS Number:
Molecular Weight:
655.12
MDL number:
NACRES:
NA.12
UNSPSC Code:
12352211
Product Name
desmosterol (D6) ester, Avanti Research™ - A Croda Brand
description
26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate)
assay
>99% (TLC)
form
methylene chloride solution
packaging
pkg of 1 × 1 mL (700184M-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
1 mg/mL (700184M-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
Biochem/physiol Actions
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
Packaging
5 mL Clear Glass Sealed Ampule (700184M-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
wgk
WGK 2
Regulatory Information
美国出口管控产品
危险化学品
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Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 700184M-1MG | 04061837665509 |