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About This Item
Empirical Formula (Hill Notation):
C24H39N5O5
CAS Number:
Molecular Weight:
477.60
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
NBD Sphingosine, omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, chloroform:methanol (8:2)
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810205X-250ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810205X
concentration
0.25 mg/mL (810205X-250ug)
shipped in
dry ice
storage temp.
−20°C
General description
Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.
Application
NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:
- as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomes
- to label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane trafficking
- to generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16
Biochem/physiol Actions
Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.
Packaging
5 mL Amber Glass Screw Cap Vial (810205X-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
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Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
>125.5 °F
flash_point_c
> 51.95 °C
Regulatory Information
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Sphingosine increases the permeability of model and cell membranes
Contreras FX, et al.
Biophysical Journal, 90(11), 4085-4092 (2006)
F-Xabier Contreras et al.
Biophysical journal, 90(11), 4085-4092 (2006-03-15)
Sphingosine, at 5-15 mol % total lipids, remarkably increases the permeability to aqueous solutes of liposomal and erythrocyte ghost membranes. The increased permeability cannot be interpreted in terms of leakage occurring at the early stages of a putative membrane solubilization
Dan-Dan Song et al.
Cell death & disease, 8(7), e2912-e2912 (2017-07-07)
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells. In both primary murine cortical neurons
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 810205X-250UG | 04061837666766 |