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810286C

Avanti

TopFluor™ Cardiolipin

Avanti Research™ - A Croda Brand

Synonym(s):

1′,3′-bis[1,2-dioleoyl-sn-glycero-3-phospho]-2′-[4-(dipyrrometheneboron difluoride) butanoyl]-sn-glycerol (ammonium salt); TopFluor-CL

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About This Item

Empirical Formula (Hill Notation):
C98H175BF2N4O18P2
CAS Number:
2260795-91-1
Molecular Weight:
1808.21
MDL number:
MFCD00036905
NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

TopFluor™ Cardiolipin, 1,1′,2,2′-tetraoleoyl cardiolipin[4-(dipyrrometheneboron difluoride)butanoyl] (ammonium salt) TopFluor™ Cardiolipin, chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810286C-100ug), pkg of 1 × 1 mL (810286C-500ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810286C

concentration

0.1 mg/mL (810286C-100ug), 0.5 mg/mL (810286C-500ug)

shipped in

dry ice

storage temp.

−20°C

General description

Cardiolipin, a unique phospholipid is present and synthesised in the inner mitochondrial membrane.
TopFluor™ cardiolipin is a fluorescent analog of the bioactive phospholipid, cardiolipin.

Biochem/physiol Actions

Cardiolipin is very much essential for the functional activity of several inner mitochondrial membrane proteins, like respiratory chain complexes. It participates in mitochondrial oxidative phosphorylation. It is also essential for proper functioning and structure of the inner mitochondrial membrane (IMM).

Packaging

5 mL Amber Glass Screw Cap Vial (810286C-100ug)
5 mL Amber Glass Screw Cap Vial (810286C-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Regulatory Information

危险化学品
易制毒化学品（2类）

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Cintia Kawai et al.
The journal of physical chemistry. B, 118(41), 11863-11872 (2014-09-24)
Fluorescence quenching of lipid-bound pyrene was used to assess the binding of cytochrome c (cyt c) to liposomes that mimic the inner mitochondrial membrane (IMM) POPC/DOPE/TOCL, with the conditions that it did or did not contain oxidized phosphatidylcholine molecules, i.e.
Functional role of cardiolipin in mitochondrial bioenergetics
Paradies G, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1837(4), 408-417 (2014)

Global Trade Item Number

SKUGTIN
810286C-100UG04061837667121
810286C-500UG04061837667138