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840875C

Avanti

18:1 PA

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); DOPA; PA(18:1(9Z)/18:1(9Z))

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About This Item

Empirical Formula (Hill Notation):
C39H72O8PNa
CAS Number:
108392-02-5
Molecular Weight:
722.95
MDL number:
MFCD00674303
UNSPSC Code:
51191904
NACRES:
NA.25
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description

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt), chloroform solution

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840875C-25mg), pkg of 2 × 20 mL (840875C-1g), pkg of 2 × 4 mL (840875C-200mg), pkg of 5 × 4 mL (840875C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (840875C-25mg), 25 mg/mL (840875C-1g), 25 mg/mL (840875C-200mg), 25 mg/mL (840875C-500mg)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].[P](=O)(OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC)(O)O

InChI

1S/C39H73O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,37H,3-16,21-36H2,1-2H3,(H2,42,43,44);/b19-17-,20-18-;/t37-;/m1./s1

InChI key

KHDHADSEKGCPKW-ZBFGHDQJSA-N

General description

18:1 PA (1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)) is a sodium salt of modified lipid which has phosphatidic acid group as the backbone.

Application

18:1 PA (1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)) has been used:
  • as a synthetic standard to identify the position of PA after iodine staining in phosphatidic acid assay by thin-layer chromatography (TLC)
  • as a lipid standard in the optimization of the liquid chromatography−mass spectrometry (LC-MS) method conditions
  • as a lipid standard in radiolabeling analysis of phospholipids

Biochem/physiol Actions

Phosphatidic acid (PA) serves as a lipid messenger. It plays a key role in mammalian target of rapamycin (mTOR) signaling.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (840875C-1g)
5 mL Clear Glass Sealed Ampule (840875C-200mg)
5 mL Clear Glass Sealed Ampule (840875C-25mg)
5 mL Clear Glass Sealed Ampule (840875C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

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Zhenping Cao et al.
Nature communications, 10(1), 5783-5783 (2019-12-21)
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Shutao Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 174, 137-142 (2013-11-28)
The poor solubility of cisplatin (CDDP) often presents a major obstacle in the formulation of CDDP in nanoparticles (NPs) by traditional methods. We have developed a novel method for synthesizing CDDP NPs taking advantage of its poor solubility. By mixing
Shireesha Sankella et al.
The Journal of biological chemistry, 289(8), 4762-4777 (2014-01-16)
In this study we examined the role of phosphatidic acid (PA) in hepatic glucose production (HGP) and development of hepatic insulin resistance in mice that lack 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). Liver lysophosphatidic acid and PA levels were increased ∼2- and
View All Related Papers

Global Trade Item Number

SKUGTIN
840875C-500MG04061837791741
840875C-1G04061837791710
840875C-200MG04061837791727
840875C-25MG04061837791734