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850150P

Avanti

18:1 PI(3)P

Avanti Research™ - A Croda Brand

Synonym(s):

PIP[3′](18:1/18:1)

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About This Item

Empirical Formula (Hill Notation):
C45H90N2O16P2
CAS Number:
1246303-09-2
Molecular Weight:
977.15
UNSPSC Code:
51191904
NACRES:
NA.25
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description

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′-phosphate) (ammonium salt)

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850150P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850150P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

InChI

1S/C45H84O16P2.2H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(46)57-35-37(59-39(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-58-63(55,56)61-45-42(50)40(48)41(49)44(43(45)51)60-62(52,53)54;;/h17-20,37,40-45,48-51H,3-16,21-36H2,1-2H3,(H,55,5

InChI key

BYXVELJOJLXSIL-ADVUQDOQSA-N

General description

Phosphatidylinositol phosphate is present in the plasma membrane.
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.

Application

18:1 PIP has been used in liposome preparation. It may also be used to generate small unilamellar vesicles for liposome flotation assays.

Biochem/physiol Actions

Phosphatidylinositol phosphate helps to promote the plasma membrane H+-ATPase of Saccharomyces cerevisiae. Phosphatidylinositol 3-phosphate (PtdIns3P) is very essential for the biogenesis of autophagosomes and their precursors.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Mariko Yokogawa et al.
The Journal of biological chemistry, 287(42), 34936-34945 (2012-08-24)
Phosphoinositides (PIs) are crucial lipid components of membranes and are involved in a number of cellular processes through interactions with their effector proteins. Recently, we have established a lipid-protein nanoscale bilayer (nanodisc) containing PIs, hereafter referred to as PI-nanodisc and
Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion
Dolat L and Spiliotis ET
The Journal of Cell Biology, 214(5), 517-527 (2016)
Richard J Chi et al.
The Journal of cell biology, 204(5), 793-806 (2014-02-26)
Retromer is an endosomal sorting device that orchestrates capture and packaging of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs). We report that fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1, a
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Global Trade Item Number

SKUGTIN
850150P-100UG04061835229536
850150P-500UG04061835229543