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850374C

Avanti

18:1 (Δ6-Cis) PC

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dipetroselinoyl-sn-glycero-3-phosphocholine; PC(18:1(6Z)/18:1(6Z))

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About This Item

Empirical Formula (Hill Notation):
C44H84NO8P
CAS Number:
56391-91-4
Molecular Weight:
786.11
MDL number:
MFCD00674313
NACRES:
NA.25
UNSPSC Code:
51191904
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Product Name

18:1 (Δ6-Cis) PC, 1,2-dipetroselenoyl-sn-glycero-3-phosphocholine, chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850374C-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850374C

concentration

10 mg/mL (850374C-25mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

General description

18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine) is a lipid derivative having a phosphocholine backbone. It also has two18 carbon fatty acid chains, each having one cis double bond at the 6th carbon.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:1 (Δ6-Cis) PC (1,2-dipetroselenoyl-sn-glycero-3-phosphocholine) may be used:
  • to generate sn-1 C18:1(Δ6-cis)- lysophosphatidylcholine (LPC) and sn-1 C18:1(Δ9-cis)-LPC standards for structural characterization of lysophosphatidylcholine (LPC) species by tandem electrospray ionization-linear ion trap-mass spectrometry (ESI-LIT-MS)
  • to study the effect on α-secretase activityin SH-SY5Y membrane
  • in liposome to study the effect of its acyl chain length and bond saturation on pore formation

Biochem/physiol Actions

Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.

Packaging

5 mL Clear Glass Sealed Ampule (850374C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）

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Felipe Gazos-Lopes et al.
PLoS neglected tropical diseases, 8(8), e3077-e3077 (2014-08-08)
Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific
Marcus O W Grimm et al.
International journal of molecular sciences, 14(3), 5879-5898 (2013-03-15)
Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving

Global Trade Item Number

SKUGTIN
850374C-25MG04061837792335