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855375P

Avanti

10:0 Lyso PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-decanoyl-sn-glycero-3-phosphocholine; PC(10:0/0:0)

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About This Item

Empirical Formula (Hill Notation):
C18H38NO7P
CAS Number:
22248-63-1
Molecular Weight:
411.47
MDL number:
MFCD00050433
UNSPSC Code:
51191904
NACRES:
NA.25
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Product Name

10:0 Lyso PC, 1-decanoyl-2-hydroxy-sn-glycero-3-phosphocholine, powder

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 25 mg (855375P-25mg), pkg of 1 × 500 mg (855375P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 855375P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCC)=O

InChI

1S/C18H38NO7P/c1-5-6-7-8-9-10-11-12-18(21)24-15-17(20)16-26-27(22,23)25-14-13-19(2,3)4/h17,20H,5-16H2,1-4H3/t17-/m1/s1

InChI key

SECPDKKEUKDCPG-QGZVFWFLSA-N

General description

Lyso-phosphatidylcholine (LPC) is a bioactive proinflammatory lipid secreted on pathological response. It has a choline group at its polar head.

Application

10:0 Lyso PC has been used as an internal standard to quantify the most abundant lysophosphatidylcholine (LPC) species found in Trypanosoma cruzi samples.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) alters various biological functions in different cell-types, such as endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells. It is associated with atherosclerosis and inflammatory diseases. LPC activates many second messengers including, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.

Packaging

20 mL Clear Glass Screw Cap Vial (855375P-500mg)
5 mL Clear Glass Sealed Ampule (855375P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Articles

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

Felipe Gazos-Lopes et al.
PLoS neglected tropical diseases, 8(8), e3077-e3077 (2014-08-08)
Trypanosoma cruzi is the causative agent of the life-threatening Chagas disease, in which increased platelet aggregation related to myocarditis is observed. Platelet-activating factor (PAF) is a potent intercellular lipid mediator and second messenger that exerts its activity through a PAF-specific
Analysis of phospholipid species in rat peritoneal surface layer by liquid chromatography/electrospray ionization ion-trap mass spectrometry
Gao F, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(7), 667-676 (2006)
Role of lysophosphatidylcholine (LPC) in atherosclerosis
Matsumoto T, et al.
Current Medicinal Chemistry, 14(30), 3209-3220 (2007)
View All Related Papers

Global Trade Item Number

SKUGTIN
855375P-25MG04061835231485
855375P-500MG04061835231492