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855475P

Avanti

12:0 Lyso PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-dodecanoyl-sn-glycero-3-phosphocholine; PC(12:0/0:0)

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About This Item

Empirical Formula (Hill Notation):
C20H42NO7P
CAS Number:
20559-18-6
Molecular Weight:
439.52
MDL number:
MFCD00133434
UNSPSC Code:
51191904
NACRES:
NA.25
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Product Name

12:0 Lyso PC, Avanti Research™ - A Croda Brand

description

1-lauroyl-2-hydroxy-sn-glycero-3-phosphocholine

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

powder

packaging

pkg of 1 × 200 mg (855475P-200mg), pkg of 1 × 25 mg (855475P-25mg), pkg of 1 × 500 mg (855475P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCC)=O

InChI

1S/C20H42NO7P/c1-5-6-7-8-9-10-11-12-13-14-20(23)26-17-19(22)18-28-29(24,25)27-16-15-21(2,3)4/h19,22H,5-18H2,1-4H3/t19-/m1/s1

InChI key

BWKILASWCLJPBO-LJQANCHMSA-N

General description

Lyso-phosphatidylcholine (LPC) is a bioactive proinflammatory lipid secreted on pathological response. It has a choline group at its polar head. Lysophosphatidylcholine (Lyso-PC) is a component of blood plasma, vascular tissue and lipoproteins.

Application

12:0 Lyso PC has been used to study its neuritogenic activity and the applications of exogenous lipids.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) alters various functions in different cell-types, like endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells. It is associated with atherosclerosis and inflammatory diseases. LPC activates many second messengers including, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.

Packaging

20 mL Clear Glass Screw Cap Vial (855475P-500mg)
5 mL Amber Glass Screw Cap Vial (855475P-200mg)
5 mL Amber Glass Screw Cap Vial (855475P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Articles

Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor
Ikeno Y, et al.
Test, 280(30) (2005)
Inner/outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis
Fichtman B, et al.
Molecular Biology of the Cell, 21(23) (2010)
Boris Fichtman et al.
Molecular biology of the cell, 21(23), 4197-4211 (2010-10-12)
Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in double nuclear membranes, which carry out nucleocytoplasmic exchange. The mechanism of nuclear pore assembly involves a unique challenge, as it requires creation of a long-lived membrane-lined channel connecting the inner
View All Related Papers

Global Trade Item Number

SKUGTIN
855475P-25MG04061835231522
855475P-200MG04061835231515
855475P-500MG04061835231539