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About This Item
Empirical Formula (Hill Notation):
C17H34O7PNa
CAS Number:
Molecular Weight:
404.41
UNSPSC Code:
51191904
NACRES:
NA.25
Product Name
14:0 Lyso PA, 1-myristoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder
assay
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
form
powder
packaging
pkg of 1 × 25 mg (857120P-25mg), pkg of 1 × 500 mg (857120P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 857120P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@](COP([O-])(O)=O)([H])COC(CCCCCCCCCCCCC)=O.[Na+]
InChI
1S/C17H35O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(19)23-14-16(18)15-24-25(20,21)22;/h16,18H,2-15H2,1H3,(H2,20,21,22);/q;+1/p-1/t16-;/m1./s1
InChI key
HGENTPHNTSLRPB-PKLMIRHRSA-M
General description
Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position.
Application
14:0 Lyso PA is suitable to use as internal standard to spike serum samples for the extraction of serum lipids. It is also suitable to use as standard lipids for extraction of lipids and for quality control in multiple reaction monitoring (MRM) assay.
Biochem/physiol Actions
Lysophosphatidic acid (LPA) participates in several biological functions. It acts as a potential biomarker for detecting ovarian cancer. LPA stimulates platelet aggregation, smooth muscle contraction, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization, neurotransmitter release and cell proliferation.
Packaging
20 mL Clear Glass Screw Cap Vial (857120P-500mg)
5 mL Amber Glass Screw Cap Vial (857120P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Determination of lysophosphatidic acids by capillary electrophoresis with indirect ultraviolet detection
Chen YL and Xu Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 355-363 (2001)
Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells
Li L, et al.
Journal of Chromatography A, 1381(2), 140-148 (2015)
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 857120P-25MG | 04061835231898 |
| 857120P-500MG | 04061835231904 |