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860409C

Avanti

9-PAHSA-d9

Avanti Research™ - A Croda Brand

Synonym(s):

9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid

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About This Item

Empirical Formula (Hill Notation):
C34H57D9O4
CAS Number:
1809222-43-2
Molecular Weight:
547.94
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
liquid
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Product Name

9-PAHSA-d9, Avanti Research™ - A Croda Brand 860409C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (860409C-1mg), pkg of 1 × 1 mL (860409C-500ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860409C

concentration

0.5 mg/mL (860409C-500ug), 1 mg/mL (860409C-1mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCC(OC(CCCCCCCCCCCC([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O)CCCCCCCC(O)=O

InChI key

MHQWHZLXDBVXML-NPNXCVMYSA-N

General description

9-PAHSA-d9 9-[((13,13,14,14,15,15,16,16,16-d9)palmitoyl)hydroxy]-stearic acid is a deuterated palmitoyl hydroxy-stearic acid wherein the nine protons of palmitoyl are replaced by deuterium. Palmitic acid-9-hydroxy-stearic acid (9-PAHSA) is the most abundantly found fatty acid ester of hydroxy fatty acids (FAHFA).
PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes. Avanti has obtained a license from the patent holder to manufacture these products for research use.

Packaging

5 mL Clear Glass Sealed Ampule (860409C-1mg)
5 mL Clear Glass Sealed Ampule (860409C-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

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Mark M Yore et al.
Cell, 159(2), 318-332 (2014-10-11)
Increased adipose tissue lipogenesis is associated with enhanced insulin sensitivity. Mice overexpressing the Glut4 glucose transporter in adipocytes have elevated lipogenesis and increased glucose tolerance despite being obese with elevated circulating fatty acids. Lipidomic analysis of adipose tissue revealed the
Matthew J Kolar et al.
Biochemistry, 55(33), 4636-4641 (2016-08-11)
A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary

Global Trade Item Number

SKUGTIN
860409C-1MG04061837667732
860409C-500UG04061837667749