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About This Item
Empirical Formula (Hill Notation):
C34H69NO2
CAS Number:
Molecular Weight:
523.92
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
N-C16-deoxysphinganine, N-palmitoyl-1-deoxysphinganine (m18:0/16:0), powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860462P-1mg), pkg of 1 × 5 mg (860462P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860462P
lipid type
sphingolipids
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
N-C16-deoxysphinganine Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The N-acyl group can be 16, 20 and 24 carbon chain. N-acylsphinganines (dihydroceramides) are synthesized by the acylation of sphingoid bases in the presence of ceramide synthases (CerS).
Commonly referred to as 1-deoxydihydroceramide (1-deoxyDHCer), this product is the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism. The biological activity of 1-deoxyDHCer is not clearly understood at this time.
Biochem/physiol Actions
N-acylsphinganines (dihydroceramides) levels are lower during ceramide synthase inhibition. They are intermediates of ceramide and dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.
Packaging
5 mL Amber Glass Screw Cap Vial (860462P-1mg)
5 mL Amber Glass Screw Cap Vial (860462P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease
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Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals
Zitomer NC, et al.
The Journal of Biological Chemistry, 284(8), 4786-4795 (2009)
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Pruett ST, et al.
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 860462P-1MG | 04061835317028 |
| 860462P-5MG | 04061835317035 |