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860476P

Avanti

1-desoxymethylsphinganine-d5

Avanti Research™ - A Croda Brand

Synonym(s):

1-Deoxymethylsphinganine-d5

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About This Item

Empirical Formula (Hill Notation):
C17H32D5NO
CAS Number:
1246298-43-0
Molecular Weight:
276.51
MDL number:
MFCD22416668
UNSPSC Code:
12352211
NACRES:
NA.25
Assay:
>99% (TLC)
Form:
powder
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Product Name

1-desoxymethylsphinganine-d5, 1-desoxymethylsphinganine-d5 (m17:0), powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860476P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860476P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](CN)([H])CCCCCCCCCCCCCC(C([2H])([2H])[2H])([2H])[2H]

InChI key

UGVBFHUWZNNKIK-RPRHKWDUSA-N

General description

Desoxymethylsphinganine is a are the major sphingoid-base present in mammals.

Application

1-desoxymethylsphinganine-d5 may be used as an internal standard for the sphingoid analysis from plasma and tissue.

Biochem/physiol Actions

Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine.

Packaging

5 mL Amber Glass Screw Cap Vial (860476P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1
Garofalo K, et al.
The Journal of Clinical Investigation, 121(12), 4735-4745 (2011)
Annelies Rotthier et al.
Human mutation, 32(6), E2211-E2225 (2011-05-28)
Hereditary sensory and autonomic neuropathy type I (HSAN-I) is an axonal peripheral neuropathy leading to progressive distal sensory loss and severe ulcerations. Mutations in SPTLC1 and SPTLC2, encoding the two subunits of serine palmitoyltransferase (SPT), the enzyme catalyzing the first
Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids
Penno A, et al.
The Journal of Biological Chemistry, 285(15), 11178-11187 (2010)
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Global Trade Item Number

SKUGTIN
860476P-1MG04061835191673