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About This Item
Empirical Formula (Hill Notation):
C34H67NO3
CAS Number:
Molecular Weight:
537.90
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860516P-10mg), pkg of 1 × 100 mg (860516P-100mg), pkg of 1 × 25 mg (860516P-25mg), pkg of 1 × 5 mg (860516P-5mg), pkg of 1 × 50 mg (860516P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1
InChI key
YDNKGFDKKRUKPY-TURZORIXSA-N
General description
Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family.
Application
C16 Ceramide (d18:1/16:0) has been used:
- as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantification
- as an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometry
- to test its effect on mitochondrial stress response in worms
Biochem/physiol Actions
C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation. C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy. The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD). It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.
Packaging
5 mL Amber Glass Screw Cap Vial (860516P-100mg)
5 mL Amber Glass Screw Cap Vial (860516P-10mg)
5 mL Amber Glass Screw Cap Vial (860516P-25mg)
5 mL Amber Glass Screw Cap Vial (860516P-50mg)
5 mL Amber Glass Screw Cap Vial (860516P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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C 16-ceramide is a natural regulatory ligand of p53 in cellular stress response
Fekry B, et al.
Nature Communications, 9(1), 4149-4149 (2018)
C16-ceramide analog combined with Pc 4 photodynamic therapy evokes enhanced total ceramide accumulation, promotion of DEVDase activation in the absence of apoptosis, and augmented overall cell killing
Separovic D, et al.
Journal of Lipids, 2011 (2011)
Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
Longato L, et al.
Oxidative Medicine and Cellular Longevity, 2012 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 860516P-100MG | 04061835317554 |
| 860516P-10MG | 04061835317561 |
| 860516P-25MG | 04061835317578 |
| 860516P-50MG | 04061835317585 |
| 860516P-5MG | 04061835317592 |