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About This Item
Empirical Formula (Hill Notation):
C42H83NO3
CAS Number:
Molecular Weight:
650.11
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860524P-10mg), pkg of 1 × 5 mg (860524P-5mg), pkg of 1 × 50 mg (860524P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+/t40-,41+/m0/s1
InChI key
ZJVVOYPTFQEGPH-AUTSUKAISA-N
General description
C24 Ceramide has long acyl chain length of 24 carbon units.
Application
C24 Ceramide (d18:1/24:0) has been used:
- in the generation of small unilamellar vesicles
- as an internal standard in liquid chromatography-mass spectrometry for ceramide quantification from rat samples
- to test its effect on mitochondrial stress response in worms
Biochem/physiol Actions
C24 ceramide induces mitochondrial stress response. Its levels are depleted in coronary artery disease (CAD). However, elevated ceramide levels is observed in Alzheimer′s disease. C24 is synthesized during stress. It mediates spontaneous neutrophil death.
Packaging
5 mL Amber Glass Screw Cap Vial (860524P-10mg)
5 mL Amber Glass Screw Cap Vial (860524P-50mg)
5 mL Amber Glass Screw Cap Vial (860524P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains
Pullmannova P, et al.
Biophysical Chemistry, 224, 20-31 (2017)
Grégory Seumois et al.
Journal of leukocyte biology, 81(6), 1477-1486 (2007-03-03)
Neutrophils rapidly undergo spontaneous apoptosis following their release from the bone marrow. Although central to leukocyte homeostasis, the mechanisms that regulate neutrophil apoptosis remain poorly understood. We show here that apoptosis of cultured neutrophils is preceded by a substantial increase
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 860524P-10MG | 04061835317721 |
| 860524P-50MG | 04061835317738 |
| 860524P-5MG | 04061835317745 |