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Merck
CN

870202C

Avanti

18:1 PDP PE

Avanti Research - A Croda Brand

Synonym(s):

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C49H84N2O9PNaS2
CAS Number:
Molecular Weight:
963.29
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

18:1 PDP PE, Avanti Research - A Croda Brand 870202C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (870202C-25mg)

manufacturer/tradename

Avanti Research - A Croda Brand 870202C

concentration

10 mg/mL (870202C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(CCSSC1=CC=CC=N1)=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

InChI

1S/C49H85N2O9PS2.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36-48(53)57-43-45(60-49(54)37-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)44-59-61(55,56)58-41-40-50-46(52)38-42-62-63-47-35-33-34-39-51-47;/h17-20,33-35,39,45H,3-16,21-32,36-38,40-44H2,1-2H3,(H,50,52)(H,55,56);/q;+1/p-1/b19-17-,20-18-;/t45-;/m1./s1

InChI key

LFMWVVNPVNIPJG-JQRYTBKHSA-M

Application

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (PDP PE 18:1) has been used as an inner lipid to synthesize high density lipoprotein-like nanoparticles (HDL-like NPs).

Packaging

5 mL Clear Glass Sealed Ampule (870202C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品(2类)

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Synthetic high-density lipoprotein-like nanoparticles potently inhibit cell signaling and production of inflammatory mediators induced by lipopolysaccharide binding Toll-like receptor 4
Foit L and Thaxton CS
Biomaterials, 100, 67-75 (2016)
Linda Foit et al.
Biomaterials, 100, 67-75 (2016-06-01)
Toll-like receptor 4 (TLR4) plays a critical role in the innate immune system. Stimulation of TLR4 occurs upon binding lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls. Due to the potency of the induced inflammatory response, there is a
Lindsay Scheetz et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(16), 4369-4380 (2020-05-23)
Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide administration; however, they have been ineffective in providing significant increases in median survival. Antigen-specific cancer vaccines and immune checkpoint blockade may provide



Global Trade Item Number

SKUGTIN
870202C-25MG04061837667978