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878112C

Avanti

C16-18:1 PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C42H84NO7P
CAS Number:
95403-34-2
Molecular Weight:
746.09
MDL number:
MFCD11974148
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

C16-18:1 PC, Avanti Research™ - A Croda Brand 878112C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (878112C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 878112C

concentration

5 mg/mL (878112C-5mg)

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COCCCCCCCCCCCCCCCC)=O

InChI key

SIEDNCDNGMIKST-IYEJTHTFSA-N

General description

C16-18:1 PC, also referred as 1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine (HOPC), is a platelet activating factor. It belongs to the class of bioactive lipids. HOPC is a mono-ether PC containing ester-linked 18:1 chain (oleoyl) at the sn-2 position and an ether-linked 16:0 chain (hexadecyl) at the sn-1 position.

Application

C16-18:1 PC or 1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine may be used: as a lipid standard for quantification of glycerophosphocholine by liquid chromatography–mass spectrometry (LC–MS), in preparation of phospholipid vesicles, as a substrate to study the substrate specificity of phospholipase B/lipase (PLB/LIP) in the presence and absence of deoxycholate (DOC).

Biochem/physiol Actions

Platelet-activating factor (PAF) acts as a lipid mediator and is involved in various inflammatory diseases.

Packaging

5 mL Clear Glass Sealed Ampule (878112C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）

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Matts Nylund et al.
Biochimica et biophysica acta, 1758(6), 807-812 (2006-06-17)
The glycolipid transfer protein (GLTP)-mediated movement of galactosylceramide from model membrane donor vesicles to acceptor vesicles is sensitive to the membrane environment surrounding the glycolipid. GLTP can catalyze the transfer of a fluorescently labeled GSL, anthrylvinyl-galactosylceramide (AV-GalCer), from vesicles composed
Akira Sato et al.
European journal of pharmacology, 745, 46-51 (2014-12-03)
Platelet-activating factor (PAF) is a potent lipid mediator that is implicated in numerous inflammatory diseases. C-reactive protein (CRP) is an acute-phase plasma protein that increases rapidly and dramatically in response to inflammation. In this study, we investigated the effect of
John J H Shin et al.
Developmental cell, 52(4), 461-476 (2020-01-14)
Phosphoinositides, diacylglycerolpyrophosphate, ceramide-1-phosphate, and phosphatidic acid belong to a unique class of membrane signaling lipids that contain phosphomonoesters in their headgroups having pKa values in the physiological range. The phosphomonoester headgroup of phosphatidic acid enables this lipid to act as

Global Trade Item Number

SKUGTIN
878112C-5MG04061838170088