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Merck
CN

880135P

Avanti

DSPE-PEG(2000) Carboxylic Acid

Avanti Research - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C131H257NNaO55P
CAS Number:
Molecular Weight:
2780.38
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

DSPE-PEG(2000) Carboxylic Acid, Avanti Research - A Croda Brand 880135P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (880135P-10mg), pkg of 1 × 100 mg (880135P-100mg), pkg of 1 × 25 mg (880135P-25mg), pkg of 1 × 50 mg (880135P-50mg), pkg of 1 × 500 mg (880135P-500mg)

manufacturer/tradename

Avanti Research - A Croda Brand 880135P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(C/C=C\OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOCCOOCC(O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=

General description

Carboxylic acids are readily soluble in polar solvents such as water and alcohols. DSPE-PEG(2000) carboxylic acid consists of a hydrophilic polyethylene glycol (PEG) chain of 2kDa.

Application

DSPE-PEG(2000) carboxylic acid has been used:
  • to covalently conjugate integrin α-2 (ITGA2) antibodies to the surface of the liposomes
  • in the preparation of atosiban-conjugated liposomes
  • to prepare dual complementary liposome

Biochem/physiol Actions

DSPE-PEG(2000) carboxylic acid increases the blood circulation time of liposomes. The carboxyl group of DSPE-PEG(2000) carboxylic acid aids in covalent conjugation with antibodies.

Packaging

20 mL Clear Glass Screw Cap Vial (880135P-500mg)
5 mL Amber Glass Screw Cap Vial (880135P-100mg)
5 mL Amber Glass Screw Cap Vial (880135P-10mg)
5 mL Amber Glass Screw Cap Vial (880135P-25mg)
5 mL Amber Glass Screw Cap Vial (880135P-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available



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Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis
Guo P, et al.
Science advances, 5(3), eaav5010-eaav5010 (2019)
ITGA2 as a potential nanotherapeutic target for glioblastoma
Guo P, et al.
Scientific reports, 9(1), 6195-6195 (2019)
Mohammad Mashreghi et al.
Nanoscale research letters, 15(1), 101-101 (2020-05-10)
In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX) with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti-EpCAM aptamer-conjugated DSPE-mPEG2000 into Caelyx® (ED-lip). The size, charge, release profile, and cytotoxicity and cellular uptake of formulation were determined. The



Global Trade Item Number

SKUGTIN
880135P-100MG04061835187690
880135P-10MG04061835187706
880135P-25MG04061835187713
880135P-500MG04061835187720
880135P-50MG04061835187737