Product Name
C8 PEG750 Ceramide, Avanti Research™ - A Croda Brand 880670P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (880670P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880670P
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCC(OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C
InChI key
NVPZJFQMNPKURK-KIAKULPZSA-N
General description
Ceramide is one of the products of sphingolipid metabolism. The ceramides differ in their acyl chain length.
Application
C8 PEG750 Ceramide has been used in ceramide liposome formulation to test a method for pH-dependent fusion between liposomes and cellular membranes using a pH low insertion peptide. It is also suitable for use in nanoliposomal formulation.
Biochem/physiol Actions
Poly-ethylene glycol (PEG) conjugated to ceramides are applicable as liposomal carriers, enclosing drug molecules. They are known to increase the circulation longevity of the drug due to its neutral surface electrostatic charge. This is inferred to decrease the negative surface charge of the liposomes preventing the release of positively charged encapsulated drug molecule.
Packaging
5 mL Amber Glass Screw Cap Vial (880670P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Xin Liu et al.
Blood, 116(20), 4192-4201 (2010-07-31)
The natural killer (NK) type of aggressive large granular lymphocytic (LGL) leukemia is a fatal illness that pursues a rapid clinical course. There are no effective therapies for this illness, and pathogenetic mechanisms remain undefined. Here we report that the
Pavan P Adiseshaiah et al.
Cancer letters, 337(2), 254-265 (2013-05-15)
Autophagy, a catabolic survival pathway, is gaining attention as a potential target in cancer. In human liver and colon cancer cells, treatment with an autophagy inducer, nanoliposomal C6-ceramide, in combination with the autophagy maturation inhibitor, vinblastine, synergistically enhanced apoptotic cell
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 880670P-25MG | 04061835192526 |