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About This Item
Empirical Formula (Hill Notation):
C38H80NBr
CAS Number:
Molecular Weight:
630.95
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (890810P-1g), pkg of 1 × 200 mg (890810P-200mg), pkg of 1 × 25 mg (890810P-25mg), pkg of 1 × 500 mg (890810P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
vaccine development
lipid type
cationic lipids
transfection
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCCCCCCC[N+](CCCCCCCCCCCCCCCCCC)(C)C.[Br-]
InChI
1S/C38H80N.BrH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(3,4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2;/h5-38H2,1-4H3;1H/q+1;/p-1
InChI key
PSLWZOIUBRXAQW-UHFFFAOYSA-M
General description
18:0 DDAB is cationic lipid and a quaternary ammonium salt. The hydrocarbon tails are saturated unlike the ionizable lipids.
Application
18:0 DDAB is suitable for the preparation of lipid-nanoparticles. It has also been used as an adjuvant and combined with monophosphoryl lipid A (MPL) for immunizing mice.
Biochem/physiol Actions
18:0 DDAB is a surface-active molecule, used as an adjuvant to induce systemic immune response. It is non-toxic.
Packaging
20 mL Clear Glass Screw Cap Vial (890810P-1g)
20 mL Clear Glass Screw Cap Vial (890810P-500mg)
5 mL Amber Glass Screw Cap Vial (890810P-200mg)
5 mL Amber Glass Screw Cap Vial (890810P-25mg)
Other Notes
For R&D use only. Not for drug, household, or other uses.
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hong Yu et al.
Infection and immunity, 78(5), 2272-2282 (2010-03-17)
Major impediments to developing a Chlamydia vaccine lie in identifying immunologically relevant T-cell antigens and delivery in a manner to stimulate protective immunity. Using an immunoproteomic approach, we previously identified three immunodominant Chlamydia T-cell antigens (PmpG-1, PmpE/F-2, and RplF). Because
Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigens
Klinguer C, et al.
Vaccine, 19(30), 4236-4244 (2001)
Ana Cristina Norberto Oliveira et al.
ACS applied materials & interfaces, 6(9), 6977-6989 (2014-04-10)
This study describes a novel liposomal formulation for siRNA delivery, based on the mixture of the neutral lipid monoolein (MO) and cationic lipids of the dioctadecyldimethylammonium (DODA) family. The cationic lipids dioctadecyldimethylammonium bromide (DODAB) and chloride (DODAC) were compared in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 890810P-25MG | 04061835534098 |
| 890810P-1G | 04061835534074 |
| 890810P-200MG | 04061835534081 |