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890890C

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C42H80NO4Cl
CAS Number:
132172-61-3
Molecular Weight:
698.54
MDL number:
MFCD01310872
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (890890C-25mg), pkg of 2 × 20 mL (890890C-1g), pkg of 2 × 4 mL (890890C-200mg), pkg of 5 × 4 mL (890890C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (890890C-25mg), 25 mg/mL (890890C-1g), 25 mg/mL (890890C-200mg), 25 mg/mL (890890C-500mg)

application(s)

advanced drug delivery

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

Application

18:1 TAP (DOTAP) has been used in the preparation of liposome-supported bilayers.

Biochem/physiol Actions

18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (890890C-1g)
5 mL Clear Glass Sealed Ampule (890890C-200mg)
5 mL Clear Glass Sealed Ampule (890890C-25mg)
5 mL Clear Glass Sealed Ampule (890890C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

危险化学品
易制毒化学品（2类）

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Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
890890C-25MG04061837668982
890890C-1G04061837668968
890890C-200MG04061837668975
890890C-500MG04061837668999