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03-32-1501

Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride

Substrate for fluorogenic assay of plasma and glandular kallikreins.

Synonym(s):

Z-Phe-Arg-7-amido-4-methylcoumarin, Hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C33H36N6O6 · xHCl
CAS Number:
70382-26-2
Molecular Weight:
612.68 (free base basis)
MDL number:
MFCD00077030
UNSPSC Code:
12352209
NACRES:
NA.83
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Quality Level

200

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

5% acetic acid: 1 mg/mL, DMSO: 1 mg/mL, water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[Cl].N([C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCNC(=N)N)C(=O)Nc2cc3c(cc2)C(=CC(=O)O3)C)C(=O)OCc1ccccc1

InChI

1S/C33H36N6O6.Cl/c1-21-17-29(40)45-28-19-24(14-15-25(21)28)37-30(41)26(13-8-16-36-32(34)35)38-31(42)27(18-22-9-4-2-5-10-22)39-33(43)44-20-23-11-6-3-7-12-23;/h2-7,9-12,14-15,17,19,26-27H,8,13,16,18,20H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,34,35,36);/t26-,27

InChI key

QNRBQTLUAIXWTG-WMXJXTQLSA-N

General description

Substrate for fluorogenic assay of plasma and glandular kallikreins. Also serves as a substrate for cathepsin B, cathepsin L, and papain.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Substrate for fluorogenic assay of plasma and glandular kallikreins
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Morita, T., et al. 1977. J. Biochem. 82, 1495.
Z-Phe-Arg-AMC, HCl

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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T Morita et al.
Journal of biochemistry, 82(5), 1495-1498 (1977-11-01)
Twenty peptide-4-methylcoumarin amides (MCA) were newly synthesized and tested as possible substrates for alpha-thrombin, factor Xa, kallikreins, urokinase, and plasmin. These fluorogenic peptides contained arginine-MCA as the carboxyl-terminus. Release of 7-amino-4-methylcoumarin was determined fluorometrically. Of these peptides, the following were

Global Trade Item Number

SKUGTIN
03-32-1501-25MG04055977206760