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1.00164

Boric acid

Name: Boric acid
Brand: MM

cryst., EMPROVE^® API, Ph. Eur., BP, NF

Synonym(s):

Orthoboric acid, Trihydroxidoboron

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About This Item

Linear Formula:

H₃BO₃

CAS Number:

10043-35-3

Molecular Weight:

61.83

UNSPSC Code:

12352106

EC Index Number:

233-139-2

MDL number:

MFCD00011337

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Properties

Quality Level

600

agency

BP, NF, Ph. Eur.

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE^® API

assay

99.5-100.5% (alkalimetric)

form

solid

potency

2660 mg/kg LD₅₀, oral (Rat), >2000 mg/kg LD₅₀, skin (Rat)

pH

3.8-4.8 (20 °C, 33 g/L in H₂O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm³ at 23 °C

bulk density

400‑600 kg/m³

anion traces

sulfate (SO₄^2-): ≤0.04%

cation traces

As: ≤0.0001%, heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
parenterals
pharmaceutical
semi-solid formulation

storage temp.

2-25°C

SMILES string

OB(O)O

InChI

1S/BH3O3/c2-1(3)4/h2-4H

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

Description

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid as an active ingredient is used in ophthalmic drugs, as antiseptic for cuts and burns, as well as antibacterial for dermatological treatments such as acne and athlete foot. Boric acid Emprove^® API is manufactured according to ICH Q7 guidelines. A CEP and an US-DMF are available.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c