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1.08486

Urea

Name: Urea
Brand: MM

crystalline, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP

Synonym(s):

Carbamide, Carbonyl diamide, Diaminomethanone, Carbonyldiamine, Carbamide, Carbonyldiamide

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About This Item

Linear Formula:

NH₂CONH₂

CAS Number:

57-13-6

Molecular Weight:

60.06

EC Index Number:

200-315-5

UNSPSC Code:

12352111

Beilstein/REAXYS Number:

635724

MDL number:

MFCD00008022

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Properties

Quality Level

500

agency

BP, ChP, JP, Ph. Eur., USP

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE^® ESSENTIAL

assay

98.0-102.0% (HPLC)

form

crystalline, solid

technique(s)

titration: suitable

pH

9 (20 °C, 100 g/L in H₂O)

mp

132-135 °C (lit.)

solubility

1000 g/L

density

1.335 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Urea is typically used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. It is useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. Urea may be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c