12-338
Wortmannin, (PI3 Kinase inhibitor)
The Wortmannin, (PI3 Kinase inhibitor) controls the biological activity of PI3 Kinase. This small molecule/inhibitor is primarily used for Biochemicals applications.
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.41
eCl@ss:
32160405
Assay:
≥95% (HPLC)
Quality Level
assay
≥95% (HPLC)
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
General description
Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.
Biochem/physiol Actions
Inhibitor Type: Kinase
Protein Target: PI3Kγ
Target Sub-Family: PI3K/PI4K
Physical form
1mg of lyophilized powder packaged under inert gas. White to off-white powder.
Preparation Note
Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.
Analysis Note
Routinely evaluated by kinase assay.
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Related Content
This paper provides an overview of PI3-kinase and what makes them unique, their implications for cancer, their roles in signal transduction and the challenges researchers face today with advancing this reserach.
Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
Ferby, I M, et al.
The Journal of Biological Chemistry, 269, 30485-30488 (1994)
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.
Nakamura, I, et al.
Febs Letters, 361, 79-84 (1995)
M J Cross et al.
The Journal of biological chemistry, 270(43), 25352-25355 (1995-10-27)
Wortmannin and its structural analogue demethoxyviridin (DMV) have been reported to be specific inhibitors of phosphatidylinositol 3-kinase activity. Here we report that these compounds are not as selective as assumed and demonstrate inhibition of bombesin-stimulated phospholipase A2 activity by both
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 12-338 | 04053252405112 |