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Dantrolene sodium salt

Name: Dantrolene sodium salt
Brand: MM

≥95% (HPLC), Ryanodine receptor blocker, solid

Synonym(s):

Dantrolene, Sodium Salt

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₉N₄O₅ · Na

CAS Number:

14663-23-1

Molecular Weight:

336.23

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00079130

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

Dantrolene, Sodium Salt, A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

Quality Level

100

description

Merck USA index - 14, 2816

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

orange

solubility

DMSO: 3 mg/mL, aqueous base: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[Na]N1C(=O)N(CC1=O)\N=C\c2[o]c(cc2)c3ccc(cc3)[N+](=O)[O-]

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChI key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

Description

General description

A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Ryanodine receptor

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c