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298711

Diethyl Pyrocarbonate

Name: Diethyl Pyrocarbonate
Brand: MM

≥97% (titration), ryanodine inhibitor, liquid

Synonym(s):

Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₀O₅

CAS Number:

1609-47-8

Molecular Weight:

162.14

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00009106

Assay:

≥97% (titration)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Product Name

Diethyl Pyrocarbonate, Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles.

Quality Level

100

description

Merck USA index - 14, 7998

assay

≥97% (titration)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

clear colorless

solubility

chloroform: soluble, ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

O(CC)C(=O)OC(=O)OCC

InChI

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

InChI key

FFYPMLJYZAEMQB-UHFFFAOYSA-N

Description

General description

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle

Product does not compete with ATP.

Reversible: no

Other Notes

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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flash_point_f

156.2 °F - closed cup

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_c

69 °C - closed cup

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
298711-100GM	04055977197952
298711-25GM	07790788049041