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341205

Etoposide

Name: Etoposide
Brand: MM

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem

Synonym(s):

Etoposide, VP-16

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₂O₁₃

CAS Number:

33419-42-0

Molecular Weight:

588.56

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00869325

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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Properties

Product Name

Etoposide, A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC₅₀ = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.

Quality Level

100

description

Merck USA index - 14, 3886

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

SMILES string

O1[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@H]3[C@@H]4[C@@H]([C@@H](c6c3cc7c(c6)OCO7)c5cc(c(c(c5)OC)O)OC)C(=O)OC4)CO[C@H]1C

InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

Description

General description

A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC₅₀ = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

A cell-permeable, topoisomerase II inhibitor (IC₅₀ = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Primary Target
topoisomerase 2

Cell permeable: yes

Target IC₅₀: 59.2 µM inhibiting topoisomerase II

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

De Lange, A.M., et al. 1995. J. Virol. 69, 2082.
Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta1175, 147.
Terada, T., et al. 1993. J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991. J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988. J. Clin. Oncol.6, 451.
Issel, B.F. 1982. Cancer Chemother. Pharmacol.7, 73.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H350,H361d

pcodes

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

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Global Trade Item Number

SKU	GTIN
341205-25MG	04055977215434