427218
FX11
≥96% (HPLC), solid, lactate dehydrogenase A inhibitor, Calbiochem®
Synonym(s):
Lactate Dehydrogenase A Inhibitor, FX11
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About This Item
Empirical Formula (Hill Notation):
C22H22O4
CAS Number:
Molecular Weight:
350.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
Assay:
≥96% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Product Name
Lactate Dehydrogenase A Inhibitor, FX11, Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
Quality Level
assay
≥96% (HPLC)
form
solid
potency
8 μM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
Application
Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
LDHA
LDHA
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Le, A., et al. 2011. Proc Natl Acad Sci USA.107, 2037.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 427218-10MG | 04055977187403 |