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5010-OP

Guanidine Hydrochloride

Name: Guanidine Hydrochloride
Brand: MM

OmniPur^® Grade, >= 99.5%, Denaturant used for purification of nucleic acids and polypeptides from cell lysates

Synonym(s):

Guanidine hydrochloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:

NH₂C(=NH)NH₂ · HCl

CAS Number:

50-01-1

Molecular Weight:

95.53

NACRES:

NA.28

UNSPSC Code:

12352107

Beilstein/REAXYS Number:

3591990

MDL number:

MFCD00013026

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Properties

Quality Level

100

form

crystalline powder (granular)

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

mp

180-185 °C (lit.)

density

1.3 g/cm³ (lit.)

foreign activity

DNAse, none detected, Phosphatase, none detected, Protease, none detected, RNAse, none detected

shipped in

ambient

storage temp.

10-30°C

SMILES string

Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

Description

General description

Denaturant used for purification of nucleic acids and polypeptides from cell lysates. Inhibits RNase and protease activity. Molecular Biology grade.br
A₂₆₀ (0.1 M, water): ≤0.05 AU
A₂₈₀ (0.1 M, water): ≤0.01 AU
Purity by Assay: ≥99.5%
DNase: None detected
Heavy metals (as Pb): ≤0.001%
Phosphatase: None detected
Protease: None detected
RNase: None detected

Intended for laboratory and manufacturing use only. Not for drug, food, or household use.

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

OMNIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H332,H315,H319

pcodes

P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c