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5.08225

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), liquid, estrogen receptor modulator, Calbiochem

Synonym(s):

InSolution Tamoxifen, 4-Hydroxy-, ( Z)-, ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen

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About This Item

Empirical Formula (Hill Notation):
C26H29NO2
CAS Number:
68047-06-3
Molecular Weight:
387.51
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00278780
Assay:
≥99% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light
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Product Name

(Z)-4-Hydroxytamoxifen, InSolution, ≥99%

Quality Level

100

assay

≥99% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

−70°C

SMILES string

N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccc(cc3)O)\c2ccccc2)(C)C

InChI

1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

DODQJNMQWMSYGS-QPLCGJKRSA-N

General description

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.
A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Estrogen receptor

Physical form

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in EtOH.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

Other Notes

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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Danger

Hazard Classifications

Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

55.4 °F - closed cup

flash_point_c

13 °C - closed cup

Regulatory Information

新产品

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Global Trade Item Number

SKUGTIN
508225000104055977261769